Our research focuses on chronic gut inflammation as a central driver of intestinal and systemic disease.

At the core of the program are inflammatory bowel diseases (IBD) and gut-brain communication, reflecting the interconnected nature of intestinal pathology and brain function. From these core areas, we investigate a broad range of disease outcomes and comorbidities, including fibrosis, colorectal cancer, impaired mucosal regeneration, fatigue, and neurodegenerative conditions such as Parkinson’s disease.

To understand how chronic gut inflammation leads to these diverse outcomes, we study key biological mechanisms, including genetic and epigenetic regulation, the microbiome, fibroblast‑driven tissue remodeling, mycotoxins, extracellular vesicles, and.

These questions are addressed using an integrated set of experimental, technological, and clinical approaches, ranging from advanced imaging and (epi)genomics to innovative organ-on-chip in vitro systems, preclinical mouse models, and multicenter clinical studies.