Publications
2026
The new IOIBD25 classification in a Belgian inception cohort of patients with inflammatory bowel disease (PANTHER)
Verstockt S , D’hooghe AT, Glorieus E, De Wolf M, Cuvry A, Lenfant M, Truyens M, Guedelha Sabino J, Ferrante M, Hens B, Geldof J, Laukens D, Cleynen I, Vermeire S, Vandermeulen L, Lobatón Ortega T and Verstockt B.
Journal of Crohn’s and Colitis 20 (Suppl_1): jjaf231.807. DOI: 10.1093/ecco-jcc/jjaf231.807.
Enduring neuroinflammation in the prefrontal cortex following chronic colitis: a role for C1q?
Lernout H, Truyens M, De Nolf C, Vandendriessche C, Bruggeman A, Xie J, Van Welden S, Lobatón Ortega T, De Vos M, Vermeirssen V, Vandenbroucke RE and Laukens D.
Journal of Crohn’s and Colitis 20 (Suppl_1): jjaf231.224. DOI: 10.1093/ecco-jcc/jjaf231.224.
2025
MH002, a Novel Butyrate-Producing Consortium of Six Commensal Bacterial Strains Has Immune-Modulatory and Mucosal-Healing Properties.
Pinheiro I, Bolca S, Van den Bossche L, Vanhove W, Van Ryckeghem S, Gottardi D, Laukens D and Possemiers S.
MH002, a Novel Butyrate-Producing Consortium of Six Commensal Bacterial Strains Has Immune-Modulatory and Mucosal-Healing Properties. International Journal of Molecular Sciences 26 (13): 6167. DOI: 10.3390/ijms26136167. PMID: 4064997
Identifying Genetic Markers of Fibrostenosis in Patients with Crohn’s Disease.
Celis J, Fouquaert S, Holvoet T, Jans D, Bossuyt P, De Kock I, Hindryckx P, Louis E, Vermeire S, De Vos M, Cleynen I and Laukens D.
Journal of Crohns and Colitis 19:i2330–32. DOI: 10.1093/ecco-jcc/jjae190.1466.
Exploring Novel in Vitro Tools to Unravel Gut-Blood-Brain Communication.
Maes L, PhD thesis. Ghent University. Faculty of Medicine and Health Sciences. Read more
Characterisation of a Human Multi-Organ-on-Chip Model to Unravel Gut-Blood-Brain Communication.
Maes L, Van Welden S, Vandenbroucke RE and Laukens D.
In Abstracts of the 20th Congress of ECCO Berlin, Germany, February 19-22, 2025, 19:i518–i518. DOI: 10.1093/ecco-jcc/jjae190.0305.
Digital Light Processing of Photo-Crosslinkable Gelatin to Create Biomimetic 3D Constructs Serving Small Intestinal Tissue Regeneration.
Maes, L, Szabó A, Van Haevermaete J, Geurs I, Dewettinck K, Vandenbroucke RE, Van Vlierberghe S and Laukens D.
Biomaterials advances 171: 214232. DOI: 10.1016/j.bioadv.2025.214232. PMID: 39983500.
MIP4IBD: An Easy and Rapid Genotyping-by-Sequencing Assay for the Inflammatory Bowel Diseases Risk Loci.
Verstockt S, Hannes L, Jans DS, Deman S, Souche E, van der Werf I, Vandermeulen L, Lobaton T, Laukens D, Verstockt B, Van Houdt J, Hoischen A, Vermeire S and Cleynen I.
Inflammatory Bowel Diseases 31 (3): 786–799. DOI: 10.1093/ibd/izae289. PMID: 39657915.
Characterisation of a human multi-organ-on-chip model to unravel gut-blood-brain communication.
Maes L, Van Welden S, Vandenbroucke RE and Laukens D.
Journal of Crohn’s and Colitis, 19 (Suppl_1): i518. DOI: 10.1093/ecco-jcc/jjae190.0305.
2024
3D Bioprinting of Gelatin Derivatives : Towards Novel Small Intestinal in Vitro Models.
Maes L, Szabó A , Van Haevermaete J, Geurs I, Dewettinck K, Van Vlierberghe S and Laukens D.
Abstracts of the 19th Congress of ECCO Stockholm, Sweden, 18: i293–i293. DOI: 10.1093/ecco-jcc/jjad212.0165.
Novel Biomarkers and Imaging Modalities for Fibrostenosing Crohn’s Disease.
Bos Simon. PhD thesis. Ghent University. Faculty of Medicine and Health Sciences.
Effect of porosity on the colonization of digital light-processed 3D hydrogel constructs toward the development of a functional intestinal model.
Szabó A, De Vlieghere E, Costa PF, Geurs I, Dewettinck K, Maes L, Laukens D and Van Vlierberghe S.
Biomacromolecules 25 (5): 2863–2874. DOI: 10.1021/acs.biomac.4c00019. PMID: 38564884.
Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson’s disease (GUT-PARFECT) : A double-blind, placebo-controlled, randomised, phase 2 Trial.
Bruggeman A, Vandendriessche C, Hamerlinck H, De Looze D, Tate DJ, Vuylsteke M, De Commer L, Devolder L, Raes J, Verhasselt B, Laukens D*, Vandenbroucke RE*, and Santens P*.
eClinicalmedicine 71 (11): 1424926 102563. DOI: 10.1016/j.eclinm.2024.102563. PMID: 38686220.
Unraveling the fatigue puzzle: Insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis.
Truyens M, Lernout H, De Vos M, Laukens D and Lobatón Ortega T.
Frontiers in Medicine 11: DOI: 10.3389/fmed.2024.1424926. PMID: 39021817.
MIP4IBD : An easy and rapid genotyping-by-sequencing assay for the inflammatory bowel diseases risk loci.
Verstockt S, Hannes L, Jans DJ, Deman S, Souche E, van der Werf I, Vandermeulen L, Lobatón Ortega T, Laukens D, Bram Verstockt B, Jeroen Van Houdt J, Alexander Hoischen A, Séverine Vermeire S, and Isabelle Cleynen I.
Inflammatory bowel diseases 31 (3): 786–799. DOI:10.1093/ibd/izae289. PMID: 39657915.
Age-related patterns in biological therapy use and surgery among patients with IBD : Insights from the Belgian PANTHER Cohort.
Celis J, Truyens M, Verstockt S, Glorieus E, De Wolf M, Lenfant M, Barbaraci M, Sabino J, Ferrante M, Geldof J, Verstockt B, Laukens D, Cleynen I, Vandermeulen L, Vermeire S, Lobatón Ortega T and IBD Res Unit.
In Abstracts of the 19th Congress of ECCO Stockholm, Sweden, February 21-24, 2024, 18:i1125–i1127. DOI: 10.1093/ecco-jcc/jjad212.0711.
2023
A comprehensive metabolite fingerprint of fibrostenosis in patients with Crohn’s disease.
Bos S, Lobatón T, De Vos M, Van Welden S, Plekhova V, De Paepe E, Vanhaecke L and Laukens D.
Scientific Reports 13 (1): 23036. DOI: 10.1038/s41598-023-50461-1. PMID: 38155265.
Reply : Serotonin in gastrointestinal disorders: Delineating peripheral versus central effects.
Laukens D and Truyens M.
Gastroenterology 164 (6): 1028–1029. DOI: 10.1053/j.gastro.2023.01.035. PMID: 36738976.
2022
Effect of 5-hydroxytryptophan on fatigue in quiescent inflammatory bowel disease: a randomized controlled trial.
Truyens M, Lobatón T, Ferrante M, Bossuyt P, Vermeire S, Pouillon L, Dewint P, Cremer A, Peeters H, Lambrecht G, Louis E, Rahier JF, Dewit O, Muls V, Holvoet T, Vandermeulen L, Peeters A, Gonzales GB, Bos S, Laukens D* and De Vos M*. (* equal contribution).
Gastroenterol. 163(5): 1294-1305.e3. DOI: 10.1053/j.gastro.2022.07.052. PMID: 35940251.
The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: A new factor in the host-microbiome interaction.
Wynendaele E, Debunne N, Janssens Y, De Spiegeleer A, Verbeke F, Tack L, Van Welden S, Goossens E, Knappe D, Hoffmann R, Van De Wiele C, Laukens D, Van Eenoo P, Vereecke L, Van Immerseel F, De Wever O and De Spiegeleer B.
BMC Biology 20(1): 151. DOI:10.1186/s12915-022-01317-z. PMID: 35761265.
The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition.
Gonzales GB, Njunge JM, Gichuki BM, Wen B, Ngari M, Potani I, Thitiri J, Laukens D, Voskuijl W, Bandsma R, Vanmassenhove J and Berkley JA.
eBioMedicine 79: 103991. DOI: 10.1016/j.ebiom.2022.103991. PMID: 35398787.
Role of integrin expression in the prediction of response to vedolizumab: a prospective real-life multicentre cohort study.
De Galan C, Gonzales GB, Van Welden S, Tavernier SJ, Lobaton T, Van Moerkercke W, Strubbe B, Peeters H, Macken E, De Vos M, Laukens D* and Hindryckx P*. (* shared last authorship).
Clin. Transl. Med. 12: e769. DOI: 10.1002/ctm2.769. PMID: 35384344.
Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury.
Devisscher L, Van Campenhout S, Lefere S, Raevens S, Tilleman L, Van Nieuwerburgh F, Van Eeckhoutte HP, Hoorens A, Lynes MA, Geerts A, Laukens D and Van Vlierberghe H.
J. Leukoc Biol. 111 (1): 123-133. DOI: 10.1002/JLB.3A0820-527R. PMID: 33724533.
2021
Long-term environmental hypoxia exposure and haematopoietic prolyl hydroxylase-1 deletion do not impact experimental Crohn’s like ileitis.
De Galan C, De Vos M, Hindryckx P*, Laukens D* and Van Welden S*. * (equal contribution).
Biology(Basel) 10 (9): 887. DOI: 10.3390/biology10090887. PMID: 3471764.
Prevalence of fatigue and unrecognized depression in patients with inflammatory bowel disease in remission under immunosuppressants and biologicals.
Truyens M, De Ruyck E, Gonzales GB, Bos S, Laukens D and De Vos M.
Journal of Clinical Medicine. 10(18): 4107. DOI: 10.3390/jcm10184107. PMID: 34575218.
Versatile human in vitro triple coculture model coincubated with adhered gut microbes reproducibly mimics pro-inflammatory host-microbe interactions in the colon.
Beterams A, De Paepe K, Maes L, Wise IJ, De Keersmaecker H, Rajkovic A, Laukens D, Van de Wiele T and Arroyo MC.
Faseb Journal 35 (12): e21992. DOI: 10.1096/fj.202101135r. PMID: 34719821.
2020
Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn’s disease.
Allais L, Verschuere S, Maes T, De Smet R, Devriese S, Gonzales G, Peeters H , Van Crombruggen K, Bachert C, De Vos M, Brusselle G, Bracke K, Cuvelier C and Laukens D.
Plos One 15 (8): e0236657. DOI: 10.1371/journal.pone.0236657. PMID: 32760089.
Metabolic modulation during intestinal fibrosis.
Bos S and Laukens D.
Journal of Digestive Diseases 21 (6): 319–325. DOI: 10.1111/1751-2980.12882. PMID: 32406133.
Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction.
Tulkens J, Vergauwen G, Van Deun J, Geeurickx E, Dhondt B, Lippens L, De Scheerder M-A, Miinalainen I, Rappu P, De Geest B, Vandecasteele K, Laukens D, Vandekerckhove L, Denys H, Vandesompele J, De Wever O and Hendrix A.
Gut 69 (1): 191-193. DOI: 10.1136/gutjnl-2018-317726. PMID: 30518529.
2019
Cellular diversity in the colon : Another brick in the wall.
Cleynen I and Laukens D.
Nature Reviews Gastroenterology & Hepatology 16 (7): 391–392. DOI: 10.1038/s41575-019-0161-7. PMID: 31160721.
Comparative performances of machine learning methods for classifying Crohn disease patients using genome-wide genotyping data.
Romagnoni A, Jégou S, Van Steen K, Wainrib G, Hugot J-P, the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Peeters H and Laukens D.
Scientific Reports 9: 10351. DOI: 10.1038/s41598-019-46649-z. PMID: 31316157.
2018
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.
Momozawa Y, Dmitrieva J, Theatre E, Deffontaine V, …, De Vos M, …, Laukens D, …, Xavier RJ, Zhang B, Zhang CK, Zhang H, Zhang W, Zhao H and Zhao ZZ.
Nature Communications 9 (1): 2427. DOI: 10.1038/s41467-018-04365-8. PMID: 29930244.
Inflammation-independent mechanisms of intestinal fibrosis : The role of the extracellular matrix.
Laukens D.
In Fibrostenotic Inflammatory Bowel Disease, edited by Florian Rieder, 77–95. Cham, Switzerland: Springer. DOI: 10.1007/978-3-319-90578-5_6.
Unmet needs in IBD : the case of fatigue.
Hindryckx P, Laukens D, D’Amico F and Danese S.
Clinical Reviews in allergy & immunology 55 (3): 368 – 378. DOI: 10.1007/s12016-017-8641-4. PMID: 28852978.
2017
Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : Markers of improved prognosis in oropharyngeal cancer.
De Meulenaere A, Vermassen T, Aspeslagh S, Deron P, Duprez F, Laukens D, Van Dorpe J, Ferdinande L and Rottey S.
Oncotarget 8 (46): 80443–80452. DOI: 10.18632/oncotarget.19045. PMID: 29113315.
Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity. Geirnaert A, Arroyo MC, Grootaert C, Laukens D, Devriese S, Smagghe G, De Vos M, Boon N and Van de Wiele T.
Scientific Reports 7 (1): 11450. DOI: 10.1038/s41598-017-11734-8. PMID: 28904372.
Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho Kinase Inhibitor.
Holvoet T, Devriese S, Castermans K, Boland S, Leysen D, Vandewynckel Y-P, Devisscher L, Van den Bossche L, Van Welden S, Dullaers M, Vandenbroucke RE, De Rycke R, Geboes K, Bourin A, Defert O, Hindryckx P, De Vos M and Laukens D.
Gastroenterology 153 (4): 1054–1067. DOI:10.1053/j.gastro.2017.06.013. PMID: 28642198.
Review Article: Dose Optimisation of Infliximab for Acute Severe Ulcerative Colitis.
Hindryckx P, Novak G, Vande Casteele N, Laukens D, Parker C, Shackelton LM, Narula N, Khanna R, Dulai P, Levesque BG, Sandborn WJ, D’Haens G, Feagan BG and Jairath V.
Alimentary Pharmacology and Therapeutics 45 (5): 617–630. DOI: 10.1111/apt.13913. PMID: 28074618.
Incidence, prevention and management of anti-drug antibodies against therapeutic antibodies in Inflammatory Bowel Disease : a Practical Overview.
Hindryckx P, Novak G, Vande Casteele N, Khanna R, Laukens D, Vipul J and Feagan BG.
Drugs 77 (4): 363–377. DOI: 10.1007/s40265-017-0693-5. PMID: 28233275.
T84 Monolayers are superior to Caco-2 as a model system of colonocytes.
Devriese S, Van den Bossche L, Van Welden S, Holvoet T, Pinheiro I, Hindryck P, De Vos M and Laukens D.
Cell Biol 148 (1): 85–93. DOI: 10.1007/s00418-017-1539-7. PMID: 28265783.
Assessment of faecal microbial transfer in Irritable Bowel Syndrome with severe bloating.
Holvoet T, Joossens M, Wang J, Boelens J, Verhasselt B, Laukens D, Van Vlierberghe H, Hindryckx P, De Vos M, De Looze D and Raes J.
Gut 66 (5): 980–982. DOI: 10.1136/gutjnl-2016-312513. PMID: 27511198.
Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice.
Van den Bossche L, Hindryckx P, Devisscher L, Devriese S, Van Welden S, Holvoet T, Vilchez Vargas R, Vital M, H Pieper DH, Vandenbussche J , Vanhaecke L, Van de Wiele T, De Vos M and Laukens D.
Applied and Environmental Microbiology 83 (7): e02766-16. DOI: 10.1128/AEM.02766-16. PMID: 28115375.
Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and Dampens Crohn’s Disease-like ileitis.
Van den Bossche L, Borsboom D, Devriese S, Van Welden S, Holvoet T, Devisscher L, Hindryckx P, De Vos M and Laukens D.
Laboratory Investigation 97 (5): 519–529. DOI: 10.1038/labinvest.2017.6. PMID: 28165466.
Haematopoietic Prolyl Hydroxylase-1 Deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.
Van Welden S, De Vos M, Wielockx B, Tavernier S, Dullaers M, Neyt S, Descamps B, Devisscher L, Devriese S, Van den Bossche L, Holvoet T, Baeyens A, Correale C, D’Alessio S, Vanhove C, De Vos F, Verhasselt B, Breier G, Lambrecht B, Janssens S, Carmeliet P, Danese S, Elewaut D, Laukens D and Hindryckx P.
Journal of Pathology 241 (4): 547–558. DOI: 10.1002/path.4861. PMID: 27981571.
Reduced mucosa-associated butyricicoccus activity in patients with ulcerative colitis correlates with aberrant claudin-1 expression.
Devriese S, Eeckhaut V, Geirnaert A, Van den Bossche L, Hindryckx P, Van de Wiele T, Van Immerseel F, Ducatelle R, De Vos M and Laukens D.
Journal of Crohn’s and Colitis 11 (2): 229–236. DOI: 10.1093/ecco-jcc/jjw142. PMID: 27484096.
2016
Next-generation proteasome inhibitor Oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma.
Vandewynckel Y-P, Coucke C, Laukens D, Devisscher L, Paridaens A, Bogaerts B, Vandierendonck A, Raevens S, Verhelst X, Van Steenkiste C, Libbrecht L, Geerts A and Van Vlierberghe H.
Oncotarget 7 (23): 37988–35000. DOI: 10.18632/oncotarget.9222. PMID: 27167000.
Genome-wide copy number variation scan identifies complement component C4 as novel susceptibility gene for Crohn’s Disease.
Cleynen I, Konings P, Robberecht C, Laukens D, Amininejad L, Théâtre E, Machiels K, Arijs I, Rutgeerts P, Louis E, Franchimont D, De Vos M, Van Steen K, Georges M, Moreau Y, Vermeesch J and Vermeire S.
Inflammatory Bowel Diseases 22 (3): 505–515. DOI: 10.1097/MIB.0000000000000623. PMID: 26595553.
Placental Growth Factor Inhibition Modulates the Interplay Between Hypoxia and Unfolded Protein Response in Hepatocellular Carcinoma.
Vandewynckel YP, Laukens D, Devisscher L, Bogaerts E, Paridaens A, Van den Bussche A, Raevens S, Verhelst X, Van Steenkiste C, Jonckx B, Libbrecht L, Geerts A, Carmeliet C and Van Vlierberghe H.
BMC Cancer 16: 9. DOI: 10.1186/s12885-015-1990-6. PMID: 26753564.
Heterogeneity of the gut microbiome in mice : guidelines for optimizing experimental design.
Laukens D, Brinkman B, Raes J, De Vos M and Vandenabeele P.
FEMS Microb. Rev. 40 (1): 117–132. DOI: 10.1093/femsre/fuv036. PMID: 26323480.
Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.
Allais L, Kerckhof F-M, Verscheure S, Bracke K, De Smet R, Laukens D, Van den Abbeele P, De Vos M, Boon N, Brusselle G, Cuvelier C and Van de Wiele T. (2016).
Environmental Microbiology. 18 (5): 1352–1363. DOI: 10.1111/1462-2920.12934. PMID: 26033517.
Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study.
Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, Brant SR, Cho JH, Daly MJ, Dubinsky M, Duerr RH, Ferguson LR, Franke A, Gearry RB, Goyette P, Hakonarson H, Halfvarson J, Hov JR, Huang H, Kennedy NA, Kupcinskas L, Lawrance IC, Lee JC, Satsangi J, Schreiber S, Théâtre E, van der Meulen-de Jong AE, Weersma RK, Wilson DC, International Inflammatory Bowel Disease Genetics Consortium, Parkes M, Vermeire S, Rioux JD, Mansfield J, Silverberg MS, Radford-Smith G, McGovern DPB, Barrett J and Lees CW.
Lancet 387: 156-167. DOI: 10.1016/S0140-6736(15)00465-1. PMID: 26490195.
2015
Validated high resolution mass spectrometry-based approach for metabolomic fingerprinting of the human gut phenotype.
Vanden Bussche J, Marzorati M, Laukens D and Vanhaecke L.
Analytical Chemistry 87 (21): 10927–10934. DOI: 10.1021/acs.analchem.5b02688. PMID: 26451617.
The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice.
Allais L, Kumar S, Debusschere K, Verschuere S, Maes T, De Smet R, Conickx G, De Vos M, Laukens D, Joos G, Brusselle G, Elewaut D, Cuvelier C and Bracke K.
Plos one 10 (11): e0141570. DOI: 10.1371/journal.pone.0141570. PMID: 26523550.
Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure. Vandewynckel, Y-P, Laukens D, Devisscher L, Paridaens A, Bogaerts E, Verhelst X, Van den Bussche A, Raevens S, Van Steenkiste C, Van Troys M, Ampe C, Descamps B, Vanhove C, Govaere O, Geerts A and Van Vlierberghe H.
Oncotarget 6 (29): 28011–28025. DOI: 10.18632/oncotarget.4377. PMID: 26293671.
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Daryani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JJY, Malekzadeh R, Westra HJ, Yamazaki K, Yang S-K, International Multiple Sclerosis Genetics Consortium, International IBD Genetics Consortium, Barrett JC, Franke A, Alizadeh BZ, Parkes M, K TB, Daly MJ, Kubo M, Anderson CA and Weersma RK.
Nature Genetics 47 (9): 979-986. DOI: 10.1038/ng.3359. PMID: 26192919.
Interindividual differences in response to treatment with butyrate-producing Butyricicoccus Pullicaecorum 25–3T studied in an in vitro gut model.
Geirnaert A, Wang J, Tinck M, Steyaert A, Van den Abbeele P, Eeckhaut V, Vilchez-Vargas R, Falony G, Laukens D, De Vos M, Van Immerseel F, Raes J, Boon N and Van de Wiele T.
FEMS Microbiology Ecology 91 (6): fiv054. DOI: 10.1093/femsec/fiv054. PMID: 25999470.
Altered expression of Caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential.
Flood B, Oficjalska K, Laukens D, Fay J, O’Grady A, Caiazza F, Heetun Z, Mills KHG, Sheahan K, Ryan EJ, Doherty GA, Kay E and Creagh EM.
Clinical and Experimental Immunology 181 (1): 39–50. DOI: 10.1111/cei.12617. PMID: 25943872.
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Anness, V, Hauser SL, Oksenberg JR, Thomsen I, Leslie, S, International Inflammatory Bowel Disease Genetics Consortium, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DPB, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A and Rioux JD.
Nature Genetics. 47 (2): 172-179. DOI: 10.1038/ng.3176. PMID: 25559196.
Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.
Steeland S, Puimège L, Vandenbroucke R, Van Hauwermeiren F, Haustraete J, Devoogdt N, Hulpiau P, Leroux-Roels G, Laukens D, Meuleman P, De Vos M and Libert C.
Journal of Biological Chemistry 290 (7): 4022–4037. DOI: 10.1074/jbc.M114.617787. PMID: 25538244.
Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for Hepatocellular Carcinoma Therapy.
Vandewynckel Y-P, Laukens D, Bogaerts E, Paridaens A, Van den Bussche A, Verhelst X, Van Steenkiste C, Descamps B, Vanhove C, Libbrecht L, De Rycke R, Lambrecht L, Geerts A, Janssens S and Van Vlierberghe H.
Hepatology International 9 (1): 93–104. DOI: 10.1007/s12072-014-9582-0. PMID: 25598862.
2014
Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death.
Laukens D, Devisscher L, Van den Bossche L, Hindryckx P, Vandenbroucke R, Vandewynckel Y-P, Cuvelier C, Brinkman B, Libert C, Vandenabeele P and De Vos M.
Laboratory Investigation 94 (12): 1419–1430. DOI: 10.1038/labinvest.2014.117. PMID; 25310532.
Hepatitis mouse models : from acute-to-chronic autoimmune hepatitis.
Yüksel M, Laukens D, Heindrickx F, Van Vlierberghe H, Geerts A, Wong FS, Wen L and Colle I.
Internationa Journal of Experimental Pathology 95 (5): 309–320. DOI: 10.1111/iep.12090. PMID: 25112417.
Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent.
Vandewynckel Y-P, Laukens D, Geerts A, Vanhove C, Descamps B, Colle I, Devisscher L, Bogaerts E, Paridaens A, Verhelst X, Van Steenkiste C, Libbrecht L, Lambrecht B, Janssens S and Van Vlierberghe H.
European Journal of Gastroenterology 26 (8): 861–870. DOI: 10.1097/MEG.0000000000000066. PMID: 24987823.
Endoplasmic reticulum stress and angiogenesis: Is there an interaction between them?
Paridaens A, Laukens D, Vandewynckel Y-P, Coulon S, Van Vlierberghe H, Geerts A and Colle I.
Liver International 34 (6): e10–e18. DOI: 10.1111/liv.12457. PMID: 24393274.
Metallothionein and stress combine to affect multiple organ systems.
Lynes MA, Hidalgo J, Manso Y, Devisscher L, Laukens D and Lawrence DA.
Cell Stress Chaperones 19 (5): 605–611. DOI: 10.1007/s12192-014-0501-z. PMID: 24584987.
Role of metallothioneins as danger signals in the pathogenesis of colitis.
Devisscher L, Hindryckx P, Lynes MA, Waeytens A, Cuvelier C, De Vos F, Vanhove C, De Vos M and Laukens D.
The Journal of Pathology 233 (1): 89–100. DOI: 10.1002/path.4330. PMID: 24452846.
2013
Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls.
Van Welden S, Laukens D, Ferdinande L, De Vos M and Hindryckx P.
Journal of Inflammation 10 (1): 36. DOI: 10.1186/1476-9255-10-36. PMID: 24257430.
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.
Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DPB, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK, Quebec IBD Genetic Consortium, NIDDK IBD Genetics Consortium, International IBD Genetics Consortium, D’Amato M, Vermeire S, Franke Q, Lettre G, Xavier RJ, Daly MJ and Rioux JD.
PLOS Genetics 9 (9): e1003723. DOI: 10.1371/journal.pgen.1003723. PMID: 24068945.
The paradox of the unfolded protein response in cancer.
Vandewynckel Y-P, Laukens D, Geerts A, Bogaerts E, Paridaens A, Verhelst X, Janssens S, Heindryckx F and Van Vlierberghe H.
Anticancer Res. 33 (11): 4683–4694. PMID: 24222102.
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, …., The UK-PSC Consortium, The International IBD Genetics Consortium, Rioux JD, Alexander G, Bergquist A, Cho J, Shreiber S, Manns MP, Färkkilä M, Dale AM, Chapman RW, Lazaridis KN, The International PSC Study Group, Franke A, Anderson CA and Karlsen TH. Nature Genetics 45 (6): 671-675. DOI: 10.1038/ng.2616. PMID: 23603763.
A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.
Possemiers S, Pinheiro I, Verhelst A, Van den Abbeele P, Maignien L, Laukens D, Reeves SG, Robinson LE, Raas T, Schneider Y-J, Van de Wiele T and Marzorati M.
Journal of Agricultural and Food Chemistry 61 (39): 9380–9392. DOI: 10.1021/jf402137r. PMID: 24006902.
Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake?
Mees G, Dierckx R, Vangestel C, Laukens D, Van Damme N and Van De Wiele C.
Molecular Imaging 12 (1): 49–58. PMID: 23348791.
2012
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Jostins L, Ripke S, Weersma RK,…., Laukens D, ….., Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.
Nature 491 (7422): 119–124. DOI: 10.1038/nature11582. PMID: 23128233.
Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis.
Vermeiren J, Hindryckx P, Van Nieuwenhuyse G, Laukens D, De Vos M, Boon N and Van de Wiele T.
Digestive Diseases and Sciences 57 (7): 1832–1837. DOI: 10.1007/s10620-012-2105-8. PMID: 22419056.
Decreased colonization of fecal Clostridium coccoides/eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment.
Vermeiren J, Van den Abbeele P, Laukens D, Vigsnæs LK, De Vos M, Boon N and Van de Wiele T.
FEMS Microbiology Ecology 79 (3): 685–696. DOI: 10.1111/j.1574-6941.2011.01252.x. PMID: 22092917.
Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion.
Pletinck A, Van Landschoot M, Steppan S, Laukens D, Passlick-Deetjen J, Vanholder R and Van Biesen W. (2012).
Nephrol. Dial. Transpl. 27 (2): 548–556. DOI: 10.1093/ndt/gfr370. PMID: 21750165.
Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion.
Pletinck A, Van Landschoot M, Steppan S, Laukens D, Passlick-Deetjen J, Vanholder R and Van Biesen W. (2012).
Nephrol. Dial. Transpl. 27 (2): 548–556. DOI: 10.1093/ndt/gfr370. PMID: 21750165.
2011
Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis.
Devisscher L, Hindryckx P, Peeters H, De Vos M and Laukens D.
Biochemical and Biophysical Research Communications 416 (3-4): 307–312. DOI: 10.1016/j.bbrc.2011.11.031. PMID: 22108053.
Involvement of endoplasmic reticulum stress in inflammatory bowel disease : a different implication for colonic and ileal disease?
Bogaert S, De Vos M, Olievier K, Peeters H, Elewaut D, Lambrecht B, Pouliot P and Laukens D.
Plos One 6 (10): e25589. DOI: 10.1371/journal.pone.0025589. PMID: 22028783.
Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia.
Hindryckx P, Devisscher L, Laukens D, Venken K, Peeters H and De Vos M.
Lab. Invest. 91 (9): 1266–1276. DOI: 10.1038/labinvest.2011.102. PMID: 21709670.
Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype.
Hindryckx P, Laukens D, Serry G, Van Praet L, Cuvelier C, Mielants H, Peeters H, Elewaut D and De Vos M.
Annals of the Rheumatic Diseases 70 (11): 2044–2048. DOI: 10.1136/ard.2010.149229. PMID: 21873332.$